Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165457 | 0.93 | EP300 (0.33) | CREBBPEP300L3MBTL1KMT2A | |
| SCHEMBL6608546 | 0.86 | HSD11B1 (0.36) | CREBBPEP300POLBL3MBTL1HSD11B1 | |
| SCHEMBL6166485 | 0.84 | EP300 (0.32) | CREBBPEP300L3MBTL1KMT2AHSD11B1 | |
| SCHEMBL6608414 | 0.82 | NTRK1 (0.33) | CREBBPEP300NTRK1POLBKMT2A | |
| SCHEMBL6607880 | 0.82 | CREBBP (0.33) | CREBBPEP300POLBKMT2ARORC | |
| SCHEMBL6609350 | 0.81 | HSD11B1 (0.36) | CREBBPEP300RORCHSD11B1 | |
| SCHEMBL6622803 | 0.81 | GABRA5 (0.34) | CREBBPEP300POLBRORC | |
| SCHEMBL6166744 | 0.80 | HSD11B1 (0.34) | CREBBPEP300HSD11B1 | |
| SCHEMBL6164284 | 0.80 | CREBBP (0.36) | CREBBPEP300L3MBTL1KMT2A | |
| SCHEMBL6626793 | 0.79 | EP300 (0.33) | CREBBPEP300HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |