SCHEMBL6608005

SCHEMBL6608005

CN1Cc2c(N)ccc(-c3cccc4ccccc34)c2C1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.40
MAPT P10636 2/20 0.40
KEAP1 Q14145 3/20 0.39
CYP3A4 P08684 2/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NFE2L2 Q16236 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
USP2 O75604 1/20 0.39
ATM Q13315 1/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
HTR7 P34969 4/20 0.38
HTR1A P08908 2/20 0.38
SLC6A2 P23975 4/20 0.38
SLC6A4 P31645 4/20 0.38
SLC6A3 Q01959 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6609106 0.76 SLC6A2 (0.42) KDM4EMAPTCYP3A4ALDH1A1HPGD
SCHEMBL6609748 0.74 NPC1 (0.48) KDM4EMAPTALDH1A1HPGDHSD17B10
SCHEMBL1334192 0.74 KEAP1 (0.62) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL30117590 0.74 KEAP1 (0.62) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL4825313 0.74 SLC6A2 (0.42) KDM4EMAPTCYP3A4ALDH1A1MEN1
SCHEMBL6077039 0.70 ALDH1A1 (0.56) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL4943495 0.68 ALDH1A1 (0.52) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL30394320 0.68 HTR7 (0.46) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL29521589 0.68 ALDH1A1 (0.65) KDM4EMAPTKEAP1CYP3A4ALDH1A1
SCHEMBL56035 0.68 ALDH1A1 (0.65) KDM4EMAPTKEAP1CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
US-6693111-B1 1H-PYRROLO(3,2-H)ISOQUINOLINE DERIVATIVES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 2004-02-17 US disclosed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US disclosed
CN-1093859-C Novel indole-2,3-done-3-oxime derivatives NEUROSEARCH AS (DK) 2002-11-06 CN disclosed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US disclosed
EP-1066037-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 2001-01-10 EP disclosed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US disclosed
EP-0781284-B1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH AS (DK) 2000-01-12 EP disclosed
WO-1999049864-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 1999-10-07 WO disclosed
CN-1207100-A Novel indole-2,3-done-3-oxime derivatives NEUROSEARCH AS (DK) 1999-02-03 CN disclosed
US-5843945-A AMPA antagonists and a method of treatment NEUROSEARCH A/S (DK) 1998-12-01 US disclosed
EP-0869958-A1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH A/S (DK) 1998-10-14 EP disclosed
US-5780493-A TREATING BRAIN DISORDERS NEUROSEARCH A/S (DK) 1998-07-14 US disclosed
WO-1998014447-A1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH A/S (DK) 1998-04-09 WO disclosed
EP-0698025-B1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH AS (DK) 1997-12-17 EP disclosed
EP-0781284-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH A/S (DK) 1997-07-02 EP disclosed
WO-1996008494-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH A/S (DK) 1996-03-21 WO disclosed
EP-0698025-A1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH A/S (DK) 1996-02-28 EP disclosed
WO-1994026747-A1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH A/S (DK) 1994-11-24 WO disclosed