Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 4/20 | 0.80 |
| ▸ | MMP9 | P14780 | 4/20 | 0.80 |
| ▸ | MMP13 | P45452 | 4/20 | 0.80 |
| ▸ | MMP2 | P08253 | 3/20 | 0.80 |
| ▸ | MMP8 | P22894 | 3/20 | 0.80 |
| ▸ | CA2 | P00918 | 2/20 | 0.80 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607579 | 0.84 | KEAP1 (0.67) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL29540847 | 0.82 | MMP13 (0.57) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL6610186 | 0.82 | MMP1 (0.64) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL22252122 | 0.79 | KEAP1 (0.73) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL22251960 | 0.78 | KEAP1 (1.00) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL7222146 | 0.78 | MMP1 (0.80) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL5654237 | 0.78 | MMP1 (0.69) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL6611402 | 0.77 | MMP1 (0.68) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL29238398 | 0.76 | MEN1 (0.51) | MMP1MMP9MMP13MMP2MMP8 | |
| SCHEMBL2513385 | 0.75 | TAS2R14 (0.70) | KEAP1TAS2R14PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147095-B1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6544984-B1 | Treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss. | AMERICAN CYANAMID COMPANY | 2003-04-08 | — | — | US | disclosed |
| EP-1147095-A1 | 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1051407-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-2000044730-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]BENZODIAZEPINE-3-HYDROXAMIC ACID AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |
| US-6071903-A | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-06-06 | — | — | US | disclosed |
| WO-1999037625-A1 | 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-07-29 | — | — | WO | disclosed |