SCHEMBL6608136

SCHEMBL6608136

O=C(Cl)c1ccccc1N1CCOCC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.53
ALDH1A1 P00352 6/20 0.50
RAB9A P51151 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
MAPT P10636 2/20 0.50
POLB P06746 1/20 0.50
CYP1A2 P05177 3/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
KDM4E B2RXH2 3/20 0.48
HPGD P15428 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2C19 P33261 2/20 0.48
CASP1 P29466 1/20 0.48
NPC1 O15118 3/20 0.47
GAA P10253 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
SLC6A9 P48067 1/20 0.46
SLC6A5 Q9Y345 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28393741 0.86 MAPT (0.53) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL27468796 0.85 AKR1C3 (0.46) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL226006 0.84 ALDH1A1 (0.57) AKR1C3ALDH1A1SMN1; SMN2MAPTPOLB
SCHEMBL29816440 0.84 ALDH1A1 (0.57) AKR1C3ALDH1A1SMN1; SMN2MAPTPOLB
SCHEMBL27315588 0.84 P2RX7 (0.51) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL28965491 0.84 NPC1 (0.66) ALDH1A1SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL325422 0.83 NPC1 (0.70) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL1286677 0.83 ALDH1A1 (0.55) AKR1C3ALDH1A1RAB9AMAPTPOLB
SCHEMBL29410870 0.83 NPC1 (0.70) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL7757288 0.83 MAPT (0.50) AKR1C3ALDH1A1RAB9ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115279747-B FYN and VEGFR2 kinase inhibitors 罗达制药生物技术有限责任公司 2024-11-05 CN disclosed
CN-115073471-B Pyrazolo tetrahydropyrrole derivative, preparation method and application thereof in medicine 沈阳药科大学 2023-03-21 CN disclosed
CN-115279747-A Novel fYN and VEGFR2 kinase inhibitors 罗达制药生物技术有限责任公司 2022-11-01 CN disclosed
CN-115073471-A Pyrazolo tetrahydropyrrole derivative, preparation method and application thereof in medicine 沈阳药科大学 2022-09-20 CN disclosed
CN-1197849-C 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors AMERICAN CYANAMID CO (US) 2005-04-20 CN disclosed
EP-1147095-B1 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS WYETH CORP (US) 2004-08-11 EP disclosed
US-6544984-B1 Treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss. AMERICAN CYANAMID COMPANY 2003-04-08 US disclosed
CN-1337952-A 2,3,4, 5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors AMERICAN CYANAMID CO (US) 2002-02-27 CN disclosed
EP-1147095-A1 2, 3, 4, 5-TETRAHYDRO-1H-[1, 4] BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS American Cyanamid Company (US) 2001-10-24 EP disclosed
US-6294698-B1 ENERGY-EFFICIENT PHOTOINITIATORS IN FORM OF ORGANIC SULFUR-CONTAINING COMPOUNDS KIMBERLY-CLARK WORLDWIDE, INC. 2001-09-25 US disclosed
CN-1293663-A 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamix acids as matrix metal-protease AMERICAN CYANAMID CO (US) 2001-05-02 CN disclosed
EP-1080118-A1 NOVEL PHOTOINITIATORS AND APPLICATIONS THEREFOR Kimberly-Clark Worldwide, Inc. (US) 2001-03-07 EP disclosed
EP-1051407-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS American Cyanamid Company (US) 2000-11-15 EP disclosed
CN-1271279-A Amide derivatives for the treatment of diseases mediated by cytokines ZENECA LTD (GB) 2000-10-25 CN disclosed
WO-2000044730-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]BENZODIAZEPINE-3-HYDROXAMIC ACID AS MATRIX METALLOPROTEINASE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-08-03 WO disclosed
US-6071903-A ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-06-06 US disclosed
WO-1999054363-A1 NOVEL PHOTOINITIATORS AND APPLICATIONS THEREFOR KIMBERLY-CLARK WORLDWIDE, INC. (US) 1999-10-28 WO disclosed
WO-1999037625-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1999-07-29 WO disclosed