Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21669330 | 0.84 | SIGMAR1 (0.59) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL960296 | 0.83 | MEN1 (0.43) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7550023 | 0.83 | TSHR (0.57) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8159313 | 0.78 | DRD2 (0.56) | HTR1AHTR7LMNASIGMAR1TSHR | |
| SCHEMBL11286821 | 0.76 | SIGMAR1 (0.64) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL11280038 | 0.76 | HTR2A (0.62) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL11280042 | 0.75 | LMNA (0.74) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL11150239 | 0.74 | SIGMAR1 (0.62) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL11439568 | 0.74 | DRD3 (0.65) | HTR1AHTR2AHTR2CHTR7HTR6 | |
| SCHEMBL4933850 | 0.73 | DRD3 (0.80) | HTR1AHTR2AHTR2CHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218352-B1 | BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE AND DOPAMINE RECEPTORS AFFINITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-05-12 | — | — | EP | disclosed |
| US-6281218-B1 | USEFUL IN THE TREATMENT OF CNS DISORDERS. | INGELHEIM ITALIA S.P.A. (IT) | 2001-08-28 | — | — | US | disclosed |