Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.54 |
| ▸ | TOP2A | P11388 | 9/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 9/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230077 | 0.85 | ADRB2 (0.50) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL8942162 | 0.85 | DPP4 (0.56) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9775925 | 0.84 | TOP2A (0.56) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9775873 | 0.84 | KDM4E (0.52) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| Water SCHEMBL8942213 | 0.84 | DPP4 (0.55) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL8942120 | 0.84 | DPP4 (0.53) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL8941979 | 0.83 | DPP4 (0.50) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL8942245 | 0.83 | DPP4 (0.49) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL5142702 | 0.82 | DPP4 (0.58) | DPP4TOP2ATOP2BCHRM2DRD1 | |
| SCHEMBL9437304 | 0.82 | TOP2A (0.58) | DPP4TOP2ATOP2BCHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140932-B1 | 1,8-BENZONAPHTHYRIDINE DERIVATIVES | AVENTIS PHARMA SA (FR) | 2004-03-17 | — | — | EP | disclosed |
| EP-1140932-A1 | 1,8-BENZONAPHTHYRIDINE DERIVATIVES | Aventis Pharma S.A. (FR) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037467-A1 | 1,8-BENZONAPHTHYRIDINE DERIVATIVES | AVENTIS PHARMA S.A. (FR) | 2000-06-29 | — | — | WO | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |