Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 6/20 | 0.49 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942316 | 0.92 | ALDH1A1 (0.50) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL9775873 | 0.89 | KDM4E (0.52) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL9775887 | 0.89 | ALDH1A1 (0.62) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL9775877 | 0.87 | ADRB2 (0.43) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL8942162 | 0.86 | DPP4 (0.56) | TOP2ATOP2BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9775884 | 0.86 | LMNA (0.52) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| Water SCHEMBL8942213 | 0.85 | DPP4 (0.55) | TOP2ATOP2BALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9786150 | 0.85 | DPP4 (0.54) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL8941979 | 0.84 | DPP4 (0.50) | TOP2ATOP2BALDH1A1KDM4EHPGD | |
| SCHEMBL6609141 | 0.84 | DPP4 (0.54) | TOP2ATOP2BALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |