Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 5/20 | 0.56 |
| ▸ | MMP9 | P14780 | 5/20 | 0.56 |
| ▸ | MMP8 | P22894 | 4/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | BMP1 | P13497 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5192024 | 0.85 | HTT (0.67) | HTTMMP2MMP9MMP8MMP13 | |
| SCHEMBL5450808 | 0.82 | ALDH1A1 (0.62) | HTTNAMPTLMNAAKR1B1MEN1 | |
| SCHEMBL5448485 | 0.80 | TAS2R14 (0.61) | TAS2R14LMNACNR2MEN1KMT2A | |
| SCHEMBL3455700 | 0.80 | HTT (1.00) | HTTNAMPTTSHRTAS2R14LMNA | |
| SCHEMBL6607386 | 0.79 | TAS2R14 (0.50) | TAS2R14AKR1B1MEN1KMT2A | |
| SCHEMBL1279080 | 0.76 | TAS2R14 (0.77) | TAS2R14BMP1CNR2 | |
| SCHEMBL1287432 | 0.75 | PSEN1 (0.79) | HTTTAS2R14MEN1KMT2A | |
| SCHEMBL2514583 | 0.75 | ALDH1A1 (0.54) | HTTTSHRLMNAAKR1B1 | |
| SCHEMBL5297763 | 0.73 | MMP2 (0.57) | HTTMMP2MMP9MMP8MMP13 | |
| SCHEMBL21643196 | 0.73 | TAS2R14 (0.62) | HTTMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451172-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037887-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |