SCHEMBL6609982

SCHEMBL6609982

N#Cc1cc(OCCCSC(F)(F)F)nc(Oc2ccnc(C(F)(F)F)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.39
LOXL2 Q9Y4K0 4/20 0.34
LOX P28300 1/20 0.34
GRM5 P41594 2/20 0.33
BLM P54132 1/20 0.33
TGFBR1 P36897 2/20 0.32
SYK P43405 3/20 0.32
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30
SCN9A Q15858 1/20 0.30
RORC P51449 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6611005 0.95 KDM4E (0.39) KDM4ELMNALOXL2LOXGRM5
SCHEMBL6612907 0.86 BLM (0.37) KDM4ELMNALOXL2LOXBLM
SCHEMBL6611694 0.85 L3MBTL1 (0.38) KDM4ELOXL2LOXBLMSYK
SCHEMBL6612640 0.85 KDM4E (0.33) KDM4ELMNAGRM5
SCHEMBL6609871 0.84 LOXL2 (0.37) LMNALOXL2LOXBLMSLC6A2
SCHEMBL6615326 0.83 POLB (0.42) KDM4ELOXL2LOX
SCHEMBL6610030 0.81 BLM (0.37) KDM4ELMNALOXL2LOXBLM
SCHEMBL6610496 0.80 L3MBTL1 (0.38) KDM4ELMNALOXL2LOXBLM
SCHEMBL6610974 0.80 KDM4E (0.33) KDM4ELMNAGRM5
SCHEMBL6609464 0.78 LOXL2 (0.38) LOXL2LOXBLMSLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1228062-B1 HERBICIDAL 2-ARYLOXY-6-FLUOROALKYLTHIOALK(EN)YLOXY-PYRIDINES BASF AG (DE) 2004-04-28 EP claimed
US-6534447-B1 2,6-disubstituted pyridine derivatives in which a fluoroalkylthioalk(en)yloxy group is attached to the pyridine group in the 2-position BASF AKTIENGESELLSCHAFT (DE) 2003-03-18 US claimed
EP-1228062-B1 HERBICIDAL 2-ARYLOXY-6-FLUOROALKYLTHIOALK(EN)YLOXY-PYRIDINES BASF AG (DE) 2004-04-28 EP disclosed
US-6534447-B1 2,6-disubstituted pyridine derivatives in which a fluoroalkylthioalk(en)yloxy group is attached to the pyridine group in the 2-position BASF AKTIENGESELLSCHAFT (DE) 2003-03-18 US disclosed
EP-1228062-A1 HERBICIDAL 2-ARYLOXY-6-FLUOROALKYLTHIOALK(EN)YLOXY-PYRIDINES BASF AKTIENGESELLSCHAFT (DE) 2002-08-07 EP disclosed
WO-2001036410-A1 HERBICIDAL 2-ARYLOXY-6-FLUOROALKYLTHIOALK(EN)YLOXY-PYRIDINE BASF AKTIENGESELLSCHAFT (DE) 2001-05-25 WO disclosed