Sugi Predict

Sugi Predict / Compounds / SCHEMBL6610089

SCHEMBL6610089

SCHEMBL6610089

COc1cccc(S(=O)(=O)Nc2cc(C(C)(C)C)cc(NC(=O)Nc3ccc(-c4ccc(CN5CCOCC5)nc4)c4ccccc34)c2OC)c1

nearest known ligand 0.81

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 2/20 0.81
▸ RAF1 P04049 2/20 0.81
▸ LYN P07948 2/20 0.81
▸ MAPK9 P45984 2/20 0.81
▸ EGFR P00533 1/20 0.81
▸ BRAF P15056 1/20 0.81
▸ EPHA2 P29317 1/20 0.81
▸ EPHA3 P29320 1/20 0.81
▸ AKT1 P31749 1/20 0.81
▸ MAPK14 Q16539 12/20 0.67
▸ SRC P12931 13/20 0.55
▸ GSK3A P49840 15/20 0.48
▸ SYK P43405 11/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ LCK P06239 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4082365 0.94 ABL1 (0.86) ABL1RAF1LYNMAPK9EGFR
SCHEMBL6610422 0.90 ABL1 (0.81) ABL1RAF1LYNMAPK9EGFR
SCHEMBL4092237 0.89 ABL1 (1.00) ABL1RAF1LYNMAPK9EGFR
SCHEMBL4456684 0.89 ABL1 (0.88) ABL1RAF1LYNMAPK9EGFR
SCHEMBL6609488 0.86 ABL1 (0.84) ABL1RAF1LYNMAPK9EGFR
SCHEMBL14376097 0.86 ABL1 (0.84) ABL1RAF1LYNMAPK9EGFR
SCHEMBL4091655 0.86 ABL1 (0.84) ABL1RAF1LYNMAPK9EGFR
SCHEMBL6613542 0.86 ABL1 (0.83) ABL1RAF1LYNMAPK9EGFR
SCHEMBL4453255 0.86 ABL1 (0.83) ABL1RAF1LYNMAPK9EGFR
SCHEMBL6053406 0.86 ABL1 (0.82) ABL1RAF1LYNMAPK9EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1381594-A1 UREA COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2004-01-21 — — EP claimed
US-6608052-B2 An mono or polycyclic aromatic or heteroaromatic carbamate or urea or thiacarbamoyl derivatives; inhibit production of cytokines involved in inflammatory processes BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2003-08-19 — — US claimed
WO-2002083642-A1 COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2002-10-24 — — WO claimed
US-20020032195-A1 Compounds useful as anti-inflammatory agents BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2002-03-14 — — US claimed
EP-1381594-A1 UREA COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2004-01-21 — — EP disclosed
US-6608052-B2 An mono or polycyclic aromatic or heteroaromatic carbamate or urea or thiacarbamoyl derivatives; inhibit production of cytokines involved in inflammatory processes BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2003-08-19 — — US disclosed
WO-2002083642-A1 COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2002-10-24 — — WO disclosed
US-20020032195-A1 Compounds useful as anti-inflammatory agents BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2002-03-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032195-A1 Compounds useful as anti-inflammatory agents MPO, EPX, PTGES ABL1 3903/4885RAF1 2166/4885LYN 2622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.