Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612409 | 0.80 | CHEK2 (0.42) | CRHR1HTTLMNACYP1A2CYP3A4 | |
| SCHEMBL5843720 | 0.73 | CRHR1 (0.51) | CRHR1MAPTNPSR1 | |
| SCHEMBL1477967 | 0.70 | MAPT (0.54) | HTTCYP3A4MAPTKMT2AALDH1A1 | |
| SCHEMBL7504044 | 0.70 | MAPT (0.51) | CRHR1HTTCYP1A2CYP2D6MAPT | |
| SCHEMBL13331926 | 0.69 | ADRA2A (0.55) | CYP3A4MAPTCYP2C19KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL3855035 | 0.69 | MAPT (0.53) | HTTCYP3A4MAPTKMT2AALDH1A1 | |
| SCHEMBL7678546 | 0.68 | CRHR1 (1.00) | CRHR1KMT2AALDH1A1 | |
| SCHEMBL5842819 | 0.68 | PARP1 (0.47) | HTTMAPTALDH1A1PARP10 | |
| SCHEMBL20919357 | 0.67 | PARP1 (0.52) | LMNACYP3A4MAPTCYP2C19KMT2A | |
| SCHEMBL23906320 | 0.67 | PLA2G10 (0.58) | HTTLMNAKMT2APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |