Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614177 | 0.93 | CCR5 (0.57) | CCR5CXCR3SIGMAR1CXCR4 | |
| SCHEMBL6612781 | 0.93 | LMNA (0.53) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL6615208 | 0.92 | CCR5 (0.61) | CCR5CXCR3SIGMAR1OPRM1CXCR4 | |
| SCHEMBL6613900 | 0.91 | CCR5 (0.63) | CCR5CXCR3SIGMAR1CXCR4 | |
| SCHEMBL6611815 | 0.91 | CCR5 (0.63) | CCR5CXCR3SIGMAR1CXCR4 | |
| SCHEMBL6012726 | 0.89 | CXCR3 (0.59) | CCR5CXCR3OPRM1 | |
| SCHEMBL6612028 | 0.88 | LMNA (0.51) | CCR5LMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6613037 | 0.87 | SIGMAR1 (0.49) | CCR5LMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6612763 | 0.86 | CCR5 (0.52) | CCR5LMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6613998 | 0.86 | OPRL1 (0.56) | CCR5LMNACHRM2ADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |