Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679702 | 0.81 | PTPN1 (0.72) | NOX1ALOX5PTPN1ALDH1A1TP53 | |
| SCHEMBL13679659 | 0.81 | NOX1 (0.61) | NOX1ALOX5PTPN1ALDH1A1TP53 | |
| SCHEMBL8797319 | 0.81 | PTPN1 (0.72) | NOX1ALOX5PTPN1ALDH1A1TP53 | |
| SCHEMBL13679657 | 0.80 | NOX1 (0.60) | NOX1ALOX5PTPN1ALDH1A1TP53 | |
| SCHEMBL6622165 | 0.80 | NOX1 (0.62) | NOX1ALOX5PTPN1CSNK1A1CSNK1D | |
| SCHEMBL6608693 | 0.80 | NOX1 (0.62) | NOX1ALOX5PTPN1ALDH1A1MAPK11 | |
| SCHEMBL13679687 | 0.79 | NOX1 (0.61) | NOX1ALOX5PTPN1CSNK1A1CSNK1D | |
| SCHEMBL6606552 | 0.78 | NOX1 (0.57) | NOX1ALOX5PTPN1ALDH1A1TP53 | |
| SCHEMBL6619832 | 0.78 | NOX1 (0.60) | NOX1ALOX5PTPN1ALDH1A1MAPK11 | |
| SCHEMBL6619898 | 0.77 | NOX1 (0.58) | NOX1ALOX5PTPN1CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |