Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668769 | 1.00 | NAMPT (0.51) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL6613975 | 0.92 | CYP11B1 (0.55) | NAMPTCYP11B1CYP11B2RAB9ALMNA | |
| SCHEMBL6646026 | 0.86 | CYP11B2 (0.43) | NAMPTCYP11B2NPC1LMNAALDH1A1 | |
| SCHEMBL6609354 | 0.84 | ABCC9 (0.53) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL5248410 | 0.84 | NAMPT (0.45) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL6615847 | 0.82 | NAMPT (0.60) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL6671955 | 0.82 | NPC1 (0.42) | NAMPTNPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL6614765 | 0.82 | NAMPT (0.55) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL6642928 | 0.81 | RAB9A (0.47) | NAMPTCYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL6612688 | 0.81 | CYP11B1 (0.54) | NAMPTCYP11B1CYP11B2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |