Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 4/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607763 | 0.96 | CYP3A4 (0.47) | CYP3A4POLBSMN1; SMN2HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL31647521 | 0.85 | PRNP (0.39) | CYP3A4SMN1; SMN2PRNPRXFP1HTR2C | |
| SCHEMBL10144361 | 0.81 | PRNP (0.50) | SMN1; SMN2PRNPRXFP1NPC1KDM4E | |
| Hydrochloric Acid SCHEMBL31648022 | 0.81 | ALOX15 (0.39) | CYP3A4SMN1; SMN2PRNPRXFP1HTR2C | |
| SCHEMBL12507660 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2PRNPRXFP1NPC1KDM4E | |
| SCHEMBL529327 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2PRNPRXFP1NPC1KDM4E | |
| SCHEMBL18389138 | 0.74 | PNMT (0.52) | PNMTCD44MAOBADRA2AADRA2B | |
| SCHEMBL12507659 | 0.74 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2PRNPRXFP1NPC1 | |
| SCHEMBL11729324 | 0.74 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2PRNPRXFP1NPC1 | |
| SCHEMBL14635533 | 0.70 | CYP3A4 (0.45) | CYP3A4POLBSMN1; SMN2HTR2CPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | claimed |
| EP-0997462-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | NIPPON KAYAKU KK (JP) | 2004-12-22 | — | — | EP | disclosed |
| US-6294547-B1 | Naphthyridine deratives or salts thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0997462-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES OR SALTS THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |