Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611399 | 0.93 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6614053 | 0.87 | ALOX15 (0.41) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6614116 | 0.86 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1SMN1; SMN2NPC1MAPT | |
| SCHEMBL6610748 | 0.86 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6613618 | 0.85 | GFER (0.44) | ALDH1A1L3MBTL1HPGDSMN1; SMN2GFER | |
| SCHEMBL5843897 | 0.85 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1CA12CA1CA4 | |
| SCHEMBL6611837 | 0.84 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6609690 | 0.84 | CRHR1 (0.38) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6609711 | 0.84 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR | |
| SCHEMBL6665519 | 0.81 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1HPGDSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |