Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611127 | 0.91 | NPSR1 (0.49) | ALDH1A1GAAMAPTPOLB | |
| SCHEMBL6611378 | 0.90 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTHPGDMEN1 | |
| SCHEMBL6609399 | 0.86 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTHSD17B10HPGD | |
| SCHEMBL6614241 | 0.85 | MEN1 (0.39) | ALDH1A1MAPTHSD17B10HPGDMEN1 | |
| SCHEMBL5842564 | 0.84 | ALDH1A1 (0.65) | ALDH1A1GAAMAPTHPGDMEN1 | |
| SCHEMBL6611399 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTHSD17B10HPGD | |
| SCHEMBL6609671 | 0.81 | BCHE (0.47) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL6610853 | 0.81 | ALOX15 (0.45) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6611423 | 0.80 | ALDH1A1 (0.43) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL6610719 | 0.79 | SLC2A1 (0.45) | ALDH1A1MAPTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |