Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611399 | 0.89 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTHPGDNPSR1 | |
| SCHEMBL6613841 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDNPSR1KDM4E | |
| SCHEMBL6611945 | 0.86 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTHPGDKDM4E | |
| SCHEMBL5842523 | 0.85 | ALDH1A1 (0.58) | ALDH1A1GAAMAPTHPGDNPSR1 | |
| SCHEMBL6609900 | 0.82 | ALOX15 (0.43) | ALDH1A1MAPTHPGDNPSR1KDM4E | |
| SCHEMBL6613611 | 0.82 | ACHE (0.42) | ALDH1A1MAPTHPGDNPSR1KDM4E | |
| SCHEMBL6611922 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPTHPGDNPSR1KDM4E | |
| SCHEMBL6611410 | 0.81 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6615359 | 0.81 | MAPT (0.39) | ALDH1A1MAPTHPGDNPSR1KDM4E | |
| SCHEMBL6614115 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |