Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.57 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 14/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | ACSL1 | P33121 | 3/20 | 0.49 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.48 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661202 | 1.00 | DGAT1 (0.57) | DGAT1SOAT1EPHX2FAAHACSL1 | |
| SCHEMBL10148092 | 1.00 | DGAT1 (0.57) | DGAT1SOAT1EPHX2FAAHACSL1 | |
| SCHEMBL10186404 | 0.85 | DGAT1 (0.53) | DGAT1SOAT1EPHX2FAAH | |
| SCHEMBL1749499 | 0.84 | ACSL1 (0.56) | DGAT1EPHX2FAAHACSL1ACSL3 | |
| SCHEMBL9572108 | 0.83 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL9572112 | 0.83 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL30045 | 0.83 | EPHX2 (0.57) | EPHX2FAAH | |
| SCHEMBL25184897 | 0.83 | POLB (0.51) | DGAT1SOAT1EPHX2ACSL1ACSL3 | |
| SCHEMBL13255507 | 0.83 | ALDH1A1 (0.60) | DGAT1EPHX2FAAHACSL1ACSL3 | |
| SCHEMBL25184896 | 0.83 | POLB (0.51) | DGAT1SOAT1EPHX2ACSL1ACSL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103108866-B | cyclohexane derivative compound | DAIICHI SANKYO Co.,Ltd. (JP) | 2015-09-09 | — | — | CN | disclosed |
| US-9051255-B2 | Piperazinyl cyclohexane compounds as GPR38 agonists | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20140221392-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| US-20140221391-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| EP-2623492-B1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2014-05-14 | — | — | EP | disclosed |
| US-8710060-B2 | Piperazinyl methyl phenyl cyclohexane compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-04-29 | — | — | US | disclosed |
| US-20130289048-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2623492-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-08-07 | — | — | EP | disclosed |
| EP-2423182-A1 | DIACYLETHYLENEDIAMINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221392-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | DGAT1 1259/4885SOAT1 197/4885EPHX2 600/4885 |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | DGAT1 1/4885SOAT1 6/4885EPHX2 1718/4885 |
| US-20140221391-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | DGAT1 1259/4885SOAT1 197/4885EPHX2 600/4885 |
| US-20130289048-A1 | CYCLOHEXANE DERIVATIVE COMPOUND | HRH2, CBR1, HRH4 | DGAT1 1259/4885SOAT1 197/4885EPHX2 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.