Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611174 | 0.89 | HPGD (0.56) | HTTSMN1; SMN2KMT2ATDP1TSHR | |
| SCHEMBL7274340 | 0.85 | ALDH1A1 (0.54) | HTTSMN1; SMN2KMT2A | |
| SCHEMBL6608892 | 0.80 | CYP1A2 (0.50) | SMN1; SMN2TDP1TSHRHPGDP2RX7 | |
| SCHEMBL4740663 | 0.78 | SMN1; SMN2 (0.76) | HTTSMN1; SMN2KMT2AHPGDP2RX7 | |
| SCHEMBL27495098 | 0.78 | HPGD (0.54) | SMN1; SMN2KMT2ATDP1TSHRHPGD | |
| Hydrochloric Acid SCHEMBL1373954 | 0.77 | SMN1; SMN2 (0.74) | HTTSMN1; SMN2KMT2AHPGDP2RX7 | |
| SCHEMBL7768685 | 0.77 | SMN1; SMN2 (0.37) | HTTSMN1; SMN2HPGD | |
| SCHEMBL6611026 | 0.75 | HPGD (0.53) | HTTSMN1; SMN2KMT2AHPGD | |
| SCHEMBL6612380 | 0.75 | L3MBTL1 (0.67) | SMN1; SMN2KMT2ATDP1PKM | |
| SCHEMBL6612241 | 0.75 | MAPT (0.52) | HTTSMN1; SMN2KMT2ATDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |