Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56627 | 0.82 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1LMNACYP2C19TPMT | |
| SCHEMBL8885796 | 0.79 | MPO (0.51) | ALDH1A1TSHRLMNACYP2C19GPR84 | |
| SCHEMBL3676992 | 0.77 | GPR84 (0.55) | GPR84 | |
| SCHEMBL9412488 | 0.75 | MAPT (0.53) | ALDH1A1HSD17B10LMNACYP2C19MAPT | |
| SCHEMBL23684463 | 0.75 | GPR84 (0.43) | SMN1; SMN2ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL4649358 | 0.74 | TSHR (0.40) | SMN1; SMN2TSHRHSD17B10GPR84CASP1 | |
| SCHEMBL14038368 | 0.70 | GPR84 (0.50) | GPR84 | |
| SCHEMBL6613866 | 0.70 | SMN1; SMN2 (0.57) | SMN1; SMN2GPR84 | |
| SCHEMBL6611433 | 0.69 | HSD17B10 (0.45) | SMN1; SMN2TSHRHSD17B10MAPT | |
| SCHEMBL3672125 | 0.69 | ALDH1A1 (0.37) | ALDH1A1LMNACYP2C19GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448196-A1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2004-08-25 | — | — | EP | claimed |
| WO-2003043634-A1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-30 | — | — | WO | claimed |
| EP-1448196-A1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003043634-A1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-30 | — | — | WO | disclosed |