Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 13/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590198 | 0.86 | HCAR2 (0.49) | GPR84 | |
| SCHEMBL8885796 | 0.83 | MPO (0.51) | TSHRGPR84KMT2A | |
| SCHEMBL3676992 | 0.81 | GPR84 (0.55) | GPR84KMT2AHCAR3 | |
| SCHEMBL56627 | 0.80 | ALDH1A1 (0.44) | GPR84SMN1; SMN2 | |
| SCHEMBL9412488 | 0.76 | MAPT (0.53) | HSD17B10GPR84POLB | |
| SCHEMBL8862204 | 0.75 | PLA2G2A (0.41) | TSHRSMN1; SMN2MEN1KMT2AHCAR3 | |
| SCHEMBL6612480 | 0.74 | SMN1; SMN2 (0.40) | TSHRCASP1CASP7HSD17B10GPR84 | |
| SCHEMBL6611480 | 0.73 | ALDH1A1 (0.40) | TSHRCASP1CASP7HSD17B10SMN1; SMN2 | |
| SCHEMBL3672125 | 0.73 | ALDH1A1 (0.37) | GPR84 | |
| SCHEMBL14966592 | 0.73 | GPR84 (0.67) | GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960367-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |