Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27598785 | 0.82 | MAPT (0.42) | ALDH1A1MAPTNPC1RAB9AESR2 | |
| SCHEMBL6309949 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL27617444 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL7707955 | 0.73 | NPC1 (0.46) | ALDH1A1MAPTNPC1RAB9AESR2 | |
| SCHEMBL27997449 | 0.72 | LMNA (0.38) | ALDH1A1MAPTNPC1RAB9APOLB | |
| SCHEMBL10872973 | 0.72 | KDM4E (0.41) | ALDH1A1RAB9AHPGDCYP1A2CYP2C9 | |
| SCHEMBL27673491 | 0.72 | LMNA (0.42) | ALDH1A1MAPTNPC1RAB9APOLB | |
| SCHEMBL27329527 | 0.71 | PDE7A (0.36) | ALDH1A1MAPTNPC1RAB9AESR2 | |
| SCHEMBL11459102 | 0.71 | KDM4E (0.38) | ALDH1A1MAPTNPC1RAB9AESR2 | |
| SCHEMBL6609300 | 0.71 | RAB9A (0.37) | ALDH1A1MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384605-A | Novel aminoalcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments | SANOFI AVENTIS (FR) | 2009-03-11 | — | — | CN | disclosed |
| EP-1461333-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003044009-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |