Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627302 | 0.89 | NPSR1 (0.48) | AKR1C3AKR1C2AKR1C1PTGS1LMNA | |
| SCHEMBL5437289 | 0.87 | PAX8 (0.55) | AKR1C3AKR1C2AKR1C1LMNASMN1; SMN2 | |
| SCHEMBL3666480 | 0.83 | AKR1C3 (0.63) | AKR1C3AKR1C2PTGS1LMNASMN1; SMN2 | |
| SCHEMBL11315398 | 0.83 | LMNA (0.53) | AKR1C3AKR1C2AKR1C1PTGS1LMNA | |
| SCHEMBL3828059 | 0.81 | AKR1C3 (0.65) | AKR1C3AKR1C2AKR1C1PTGS1LMNA | |
| SCHEMBL1741211 | 0.79 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1PTGS1LMNA | |
| SCHEMBL2976175 | 0.79 | FDPS (0.56) | AKR1C3AKR1C2AKR1C1PTGS1TSHR | |
| SCHEMBL24182305 | 0.78 | ACHE (0.67) | PTGS1LMNASMN1; SMN2NPC1USP2 | |
| SCHEMBL5496986 | 0.78 | LMNA (0.46) | LMNASMN1; SMN2NPSR1TSHRALDH1A1 | |
| SCHEMBL1574429 | 0.78 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1PTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392663-A2 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS, PREPARATION AND USES THEREOF | NEURO3D (FR) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098865-A2 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS, PREPARATION AND USES THEREOF | NEURO3D (FR) | 2002-12-12 | — | — | WO | disclosed |
| WO-2002088096-A1 | COMPOUNDS INHIBITING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES THEREOF | NEURO3D (FR) | 2002-11-07 | — | — | WO | disclosed |