Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613347 | 1.00 | APOL1 (0.37) | APOL1DDB1CRBNMAP2K1PSEN1 | |
| SCHEMBL6613404 | 0.85 | CRBN (0.37) | APOL1DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL6613398 | 0.85 | CRBN (0.37) | APOL1DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL6645767 | 0.83 | FPR2 (0.36) | APOL1DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL6645760 | 0.83 | FPR2 (0.36) | APOL1DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL6650942 | 0.80 | APOL1 (0.36) | APOL1DDB1CRBN | |
| SCHEMBL6672070 | 0.80 | KDM4E (0.41) | MAP2K1ALDH1A1 | |
| SCHEMBL6672074 | 0.80 | KDM4E (0.41) | MAP2K1ALDH1A1 | |
| SCHEMBL6614624 | 0.78 | CCNC (0.35) | APOL1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6614630 | 0.78 | CCNC (0.35) | APOL1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456172-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053925-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-07-03 | — | — | WO | disclosed |