Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | APOL1 | O14791 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645767 | 1.00 | FPR2 (0.36) | FPR2FPR1USP30PSEN1PSEN2 | |
| SCHEMBL6613398 | 0.83 | CRBN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613347 | 0.83 | APOL1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613404 | 0.83 | CRBN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613354 | 0.83 | APOL1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6618579 | 0.81 | ALDH1A1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6618582 | 0.81 | ALDH1A1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6645804 | 0.79 | APOL1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6650942 | 0.78 | APOL1 (0.36) | FPR2APOL1DDB1CRBN | |
| SCHEMBL6672070 | 0.76 | KDM4E (0.41) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456172-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053925-A1 | PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-07-03 | — | — | WO | disclosed |