Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | CCR5 | P51681 | 6/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610245 | 0.97 | CCR3 (0.51) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL6615585 | 0.95 | CCR5 (0.52) | SIGMAR1CCR5CXCR4CCR3 | |
| SCHEMBL7483160 | 0.95 | CCR5 (0.52) | SIGMAR1CCR5CXCR4CCR3 | |
| SCHEMBL6612028 | 0.93 | LMNA (0.51) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL6613037 | 0.92 | SIGMAR1 (0.49) | SIGMAR1CCR5CXCR4KMT2A | |
| SCHEMBL6611259 | 0.92 | SIGMAR1 (0.50) | SIGMAR1CCR5CXCR4CCR3 | |
| SCHEMBL6614177 | 0.89 | CCR5 (0.57) | SIGMAR1CCR5CXCR4 | |
| SCHEMBL6612763 | 0.88 | CCR5 (0.52) | OPRM1SIGMAR1CCR5CXCR4CCR3 | |
| SCHEMBL6615174 | 0.88 | OPRL1 (0.61) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| SCHEMBL6614708 | 0.88 | CCR5 (0.47) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |