Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618535 | 0.98 | CNR1 (0.41) | CNR1CRACR2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6618955 | 0.94 | JAK2 (0.40) | CNR1CRACR2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6617159 | 0.91 | JAK2 (0.38) | CRACR2ANPC1RAB9AJAK2TYK2 | |
| SCHEMBL6620569 | 0.91 | CNR1 (0.41) | CNR1CRACR2ARAB9ASMN1; SMN2POLB | |
| SCHEMBL6617620 | 0.89 | CNR1 (0.42) | CNR1CRACR2ASMN1; SMN2POLBKCNJ6 | |
| SCHEMBL6618981 | 0.89 | JAK2 (0.40) | CNR1CRACR2APOLBJAK2TYK2 | |
| SCHEMBL6618467 | 0.88 | RAB9A (0.39) | CNR1CRACR2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6622866 | 0.88 | KDM4E (0.40) | CNR1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL6617364 | 0.88 | CNR1 (0.42) | CNR1CRACR2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6651075 | 0.87 | KMT2A (0.39) | CNR1RAB9APOLBKCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |