Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606378 | 0.91 | CNR1 (0.40) | LMNACNR1MAPTNPC1ALDH1A1 | |
| SCHEMBL6651075 | 0.91 | KMT2A (0.39) | KDM4ELMNACNR1TDP1RAB9A | |
| SCHEMBL6616981 | 0.90 | GNRHR (0.41) | KDM4EMAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL6615258 | 0.88 | CNR1 (0.41) | KDM4ECNR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6618768 | 0.88 | MEN1 (0.46) | MAPTNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6620279 | 0.87 | KMT2A (0.38) | KDM4ECNR1KMT2AMEN1KCNJ6 | |
| SCHEMBL6620336 | 0.87 | POLB (0.40) | KDM4ELMNACNR1TDP1NPC1 | |
| SCHEMBL6618535 | 0.86 | CNR1 (0.41) | KDM4ECNR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6620569 | 0.86 | CNR1 (0.41) | KDM4ELMNACNR1TDP1MAPT | |
| SCHEMBL6614591 | 0.86 | P2RY14 (0.42) | KDM4EMAPTSMN1; SMN2TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |