Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618955 | 0.94 | JAK2 (0.40) | JAK2TYK2NPC1RAB9AJAK1 | |
| SCHEMBL6615258 | 0.91 | CNR1 (0.41) | JAK2TYK2NPC1RAB9AJAK1 | |
| SCHEMBL6618535 | 0.89 | CNR1 (0.41) | JAK2TYK2NPC1RAB9AJAK1 | |
| SCHEMBL6618981 | 0.89 | JAK2 (0.40) | JAK2TYK2JAK1CRACR2ACDK9 | |
| SCHEMBL6621181 | 0.88 | LMNA (0.40) | JAK2TYK2NPC1RAB9AJAK1 | |
| SCHEMBL6616981 | 0.88 | GNRHR (0.41) | NPC1RAB9AEPHX2L3MBTL1KMT2A | |
| SCHEMBL6609028 | 0.88 | TYK2 (0.43) | JAK2TYK2JAK1CRACR2ACDK9 | |
| SCHEMBL6620229 | 0.88 | PPARG (0.42) | NPC1RAB9APPARGEPHX2CRACR2A | |
| SCHEMBL6619665 | 0.87 | P2RY14 (0.41) | NPC1RAB9AEPHX2TP53 | |
| SCHEMBL6618279 | 0.87 | MAPK14 (0.41) | NPC1RAB9AUSP2THRBACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |