Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647398 | 0.93 | KMT2A (0.38) | KMT2AMEN1HTTKDM4ELMNA | |
| SCHEMBL6622866 | 0.91 | KDM4E (0.40) | KMT2AMEN1CNR1KDM4ELMNA | |
| SCHEMBL6620279 | 0.89 | KMT2A (0.38) | KMT2AMEN1CNR1KDM4EKCNJ6 | |
| SCHEMBL6620336 | 0.89 | POLB (0.40) | KMT2AMEN1CNR1KDM4ELMNA | |
| SCHEMBL6614591 | 0.89 | P2RY14 (0.42) | KDM4EPOLBNAMPTTP53 | |
| SCHEMBL6617294 | 0.88 | SLC1A2 (0.39) | KMT2ACNR1KDM4EPOLBNAMPT | |
| SCHEMBL6615258 | 0.87 | CNR1 (0.41) | CNR1KDM4EKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6620569 | 0.87 | CNR1 (0.41) | KMT2ACNR1KDM4ELMNAKCNJ6 | |
| SCHEMBL6624191 | 0.86 | CRACR2A (0.46) | HTTCNR1KDM4ELMNATDP1 | |
| SCHEMBL6603139 | 0.85 | BRAF (0.40) | KMT2AMEN1CNR1LMNAKCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |