Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615797 | 0.92 | DRD2 (0.43) | DRD2KDM4ERAB9AGLAKMT2A | |
| SCHEMBL6616711 | 0.90 | NPC1 (0.40) | DRD2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL6617460 | 0.89 | KDM4C (0.39) | KDM4CKDM4ERAB9AGLAKMT2A | |
| SCHEMBL6618198 | 0.88 | RAB9A (0.41) | KDM4CKDM4ERAB9AGLAKMT2A | |
| SCHEMBL6619748 | 0.88 | ALDH1A1 (0.38) | DRD2KDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL6618824 | 0.87 | HRH3 (0.41) | DRD2KDM4EADRA1AHRH3 | |
| SCHEMBL6618430 | 0.87 | ALDH1A1 (0.38) | DRD2KDM4CKDM4ERAB9AHTT | |
| SCHEMBL6620292 | 0.86 | PTGES (0.40) | DRD2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6615885 | 0.86 | NPC1 (0.47) | KDM4CKDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL6617920 | 0.85 | KMT2A (0.40) | DRD2KDM4ERAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |