Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.36 |
| ▸ | STAT5A | P42229 | 1/20 | 0.36 |
| ▸ | STAT5B | P51692 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615977 | 0.90 | LMNA (0.42) | NAMPTMAPTHDAC1TP53JAK2 | |
| SCHEMBL6619769 | 0.88 | LMNA (0.40) | MAPTHDAC1SMN1; SMN2LMNAACKR3 | |
| SCHEMBL6618316 | 0.87 | MAPT (0.42) | NAMPTMAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL6614876 | 0.87 | MEN1 (0.43) | NAMPTMAPTHDAC1TP53JAK2 | |
| SCHEMBL6616244 | 0.87 | NAMPT (0.41) | NAMPTMAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL6614537 | 0.86 | ACKR3 (0.41) | MAPTTP53SMN1; SMN2LMNAACKR3 | |
| SCHEMBL6617954 | 0.86 | EPHX2 (0.40) | NAMPTJAK2PTGDR2CHRNE | |
| SCHEMBL6622320 | 0.86 | MAPT (0.42) | MAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL6616321 | 0.86 | CHRNE (0.38) | NAMPTCHRNELMNAROCK2 | |
| SCHEMBL6615537 | 0.85 | LMNA (0.45) | NAMPTMAPTHDAC1TP53JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |