Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.55 |
| ▸ | ITGB7 | P26010 | 7/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616257 | 1.00 | ALDH1A1 (0.60) | ALDH1A1ITGA4ITGB7ATMKDM4A | |
| SCHEMBL14921097 | 0.87 | ALDH1A1 (0.66) | ALDH1A1ITGA4ITGB7KDM4APTPN1 | |
| SCHEMBL7513811 | 0.85 | ITGA4 (0.51) | ALDH1A1ITGA4ITGB7ATM | |
| SCHEMBL5842386 | 0.84 | ALDH1A1 (0.49) | ALDH1A1PTPN1 | |
| SCHEMBL3970236 | 0.83 | ALDH1A1 (0.57) | ALDH1A1ITGA4ITGB7KDM4A | |
| SCHEMBL3970237 | 0.83 | ALDH1A1 (0.57) | ALDH1A1ITGA4ITGB7KDM4A | |
| SCHEMBL6806963 | 0.81 | ITGA4 (0.59) | ITGA4ITGB7ATM | |
| SCHEMBL6801977 | 0.81 | ITGA4 (0.59) | ITGA4ITGB7ATM | |
| SCHEMBL14921093 | 0.81 | ALDH1A1 (0.46) | ALDH1A1PTPN1 | |
| SCHEMBL5276860 | 0.80 | ALDH1A1 (0.50) | ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481975-A1 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-0892797-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL MYERS SQUIBB CO (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0892797-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997030992-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |