Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6660284 | 0.94 | ACKR3 (0.42) | ACKR3P2RY14MAPTSMN1; SMN2LMNA | |
| SCHEMBL6619665 | 0.92 | P2RY14 (0.41) | P2RY14MAPTTP53POLBKCNJ6 | |
| SCHEMBL6614591 | 0.91 | P2RY14 (0.42) | P2RY14MAPTSMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL6605931 | 0.89 | ACKR3 (0.43) | ACKR3MAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL6618955 | 0.89 | JAK2 (0.40) | ACKR3MAPTSMN1; SMN2LMNARXFP1 | |
| SCHEMBL6613507 | 0.88 | MAPT (0.42) | P2RY14MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL6618105 | 0.88 | CCR2 (0.40) | MAPTSMN1; SMN2LMNATP53POLB | |
| SCHEMBL6617337 | 0.87 | CNR1 (0.39) | ACKR3MAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL6606378 | 0.87 | CNR1 (0.40) | ACKR3MAPTSMN1; SMN2LMNAPKM | |
| SCHEMBL6617708 | 0.87 | ACKR3 (0.41) | ACKR3MAPTSMN1; SMN2LMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |