Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623103 | 0.94 | MAPK14 (0.40) | P2RY14POLBMAPK14MAPTEPHX2 | |
| SCHEMBL6614591 | 0.92 | P2RY14 (0.42) | P2RY14POLBMAPK14MAPTBCHE | |
| SCHEMBL6616371 | 0.92 | ACKR3 (0.43) | P2RY14POLBMAPTTP53ROCK2 | |
| SCHEMBL6618867 | 0.90 | TP53 (0.41) | POLBMAPK14MAPTEPHX2TP53 | |
| SCHEMBL6617061 | 0.90 | TAOK1 (0.42) | POLBMAPK14MAPTEPHX2TP53 | |
| SCHEMBL6613507 | 0.89 | MAPT (0.42) | P2RY14POLBMAPK14MAPTNAMPT | |
| SCHEMBL6603910 | 0.88 | NAMPT (0.42) | POLBMAPK14EPHX2ROCK2NAMPT | |
| SCHEMBL6616981 | 0.88 | GNRHR (0.41) | POLBMAPTEPHX2BCHETP53 | |
| SCHEMBL6617159 | 0.87 | JAK2 (0.38) | EPHX2TP53NPC1RAB9A | |
| SCHEMBL6673259 | 0.87 | NAMPT (0.41) | POLBMAPK14MAPTROCK2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |