Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618867 | 0.91 | TP53 (0.41) | NR1H4EPHX2SMN1; SMN2MAPTPPARG | |
| SCHEMBL6615869 | 0.91 | NAMPT (0.41) | NR1H4EPHX2SMN1; SMN2MAPTTRPV1 | |
| SCHEMBL6616371 | 0.89 | ACKR3 (0.43) | ACKR3SMN1; SMN2LMNAMAPTL3MBTL1 | |
| SCHEMBL6613041 | 0.88 | TRPV1 (0.44) | ACKR3NR1H4EPHX2SMN1; SMN2LMNA | |
| SCHEMBL6617248 | 0.88 | NR1H4 (0.41) | NR1H4EPHX2SMN1; SMN2LMNAMAPT | |
| SCHEMBL6603129 | 0.87 | TP53 (0.41) | ACKR3SMN1; SMN2LMNAMAPTRAB9A | |
| SCHEMBL6616194 | 0.86 | RAB9A (0.46) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL6621456 | 0.86 | MEN1 (0.44) | NR1H4SMN1; SMN2NPC1RAB9ATRPV1 | |
| SCHEMBL6618415 | 0.86 | MEN1 (0.44) | ACKR3NR1H4EPHX2LMNAMAPT | |
| SCHEMBL6617192 | 0.85 | MAPT (0.43) | ACKR3NR1H4EPHX2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |