Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620401 | 0.90 | HRH3 (0.39) | EPHX2HRH3TAOK1TAOK3MEN1 | |
| SCHEMBL6616492 | 0.90 | HRH3 (0.38) | EPHX2HRH3SMN1; SMN2TAOK1TAOK3 | |
| SCHEMBL6616656 | 0.89 | LMNA (0.39) | EPHX2HRH3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6618795 | 0.88 | HRH3 (0.40) | EPHX2HRH3MAPTLMNARAB9A | |
| SCHEMBL6616443 | 0.88 | CRACR2A (0.42) | HRH3MAPTPTGES | |
| SCHEMBL6618824 | 0.88 | HRH3 (0.41) | EPHX2HRH3TAOK1TAOK3PTGES | |
| SCHEMBL6618198 | 0.87 | RAB9A (0.41) | HRH3HSD17B10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6616965 | 0.86 | HRH3 (0.40) | EPHX2HRH3SMN1; SMN2TAOK1TAOK3 | |
| SCHEMBL6617392 | 0.86 | MEN1 (0.41) | HRH3SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL6617603 | 0.86 | CHRNE (0.45) | EPHX2MEN1KMT2AKDM5AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |