Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | GLP1R | P43220 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618795 | 0.92 | HRH3 (0.40) | PAX8MAPTPTGESHRH3 | |
| SCHEMBL6616751 | 0.91 | CRACR2A (0.45) | CRACR2AMAPTALDH1A1AVPR2PTGES | |
| SCHEMBL6615270 | 0.90 | CRACR2A (0.44) | CRACR2AMAPTALDH1A1 | |
| SCHEMBL6619198 | 0.90 | CRACR2A (0.44) | CRACR2AMAPTAVPR2PTGESDHODH | |
| SCHEMBL6616448 | 0.89 | EPHX2 (0.40) | PAX8MAPTALDH1A1HRH3 | |
| SCHEMBL6617233 | 0.88 | NPC1 (0.43) | CRACR2AMAPT | |
| SCHEMBL6616656 | 0.88 | LMNA (0.39) | CCR3MAPTALDH1A1CHRM1HRH3 | |
| SCHEMBL6614045 | 0.88 | EPHX2 (0.41) | MAPTPTGESHRH3 | |
| SCHEMBL6615915 | 0.88 | PAX8 (0.49) | CCR3PAX8MAPTCHRM1KCNMA1 | |
| SCHEMBL6618455 | 0.87 | LMNA (0.39) | CRACR2AMAPTALDH1A1DHODHCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |