Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 9/20 | 0.40 |
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617216 | 0.89 | HPGD (0.43) | ALDH1A1HPGDCRACR2ACYP3A4 | |
| SCHEMBL6609028 | 0.89 | TYK2 (0.43) | HPGDTYK2JAK2CRACR2AJAK1 | |
| SCHEMBL6620323 | 0.87 | TYK2 (0.41) | TYK2JAK2CRACR2AJAK1ITGB1 | |
| SCHEMBL6617587 | 0.87 | JAK2 (0.36) | ALDH1A1HPGDTYK2JAK2CRACR2A | |
| SCHEMBL6618981 | 0.87 | JAK2 (0.40) | TYK2JAK2CRACR2AJAK1ITGB1 | |
| SCHEMBL6618955 | 0.87 | JAK2 (0.40) | TYK2JAK2CRACR2AJAK1ITGB1 | |
| SCHEMBL6617940 | 0.86 | ALDH1A1 (0.38) | ALDH1A1HPGDKMT2A | |
| SCHEMBL6603404 | 0.86 | RAB9A (0.40) | ALDH1A1HPGDKMT2A | |
| SCHEMBL6619685 | 0.85 | JAK2 (0.43) | HPGDTYK2JAK2CRACR2AJAK1 | |
| SCHEMBL6619381 | 0.85 | HRH3 (0.43) | TYK2JAK2CRACR2AJAK1ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |