Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 6/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
| ▸ | CDK14 | O94921 | 5/20 | 0.33 |
| ▸ | CCNY | Q8ND76 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617797 | 0.91 | TYK2 (0.42) | JAK2TYK2JAK1HPGDITGB1 | |
| SCHEMBL6617161 | 0.87 | ALDH1A1 (0.42) | JAK2TYK2JAK1ALDH1A1HPGD | |
| SCHEMBL6620323 | 0.86 | TYK2 (0.41) | JAK2TYK2JAK1ITGB1ITGA4 | |
| SCHEMBL6609028 | 0.84 | TYK2 (0.43) | JAK2TYK2JAK1HPGDITGB1 | |
| SCHEMBL6616450 | 0.84 | POLB (0.36) | JAK2TYK2JAK1ALDH1A1ITGB1 | |
| SCHEMBL6618849 | 0.82 | CHRM5 (0.40) | CRACR2ANPC1RAB9A | |
| SCHEMBL6616958 | 0.81 | ALDH1A1 (0.39) | JAK2ALDH1A1HPGDCRACR2AMEN1 | |
| SCHEMBL6603775 | 0.81 | TYK2 (0.41) | JAK2TYK2JAK1ITGB1ITGA4 | |
| SCHEMBL6615827 | 0.80 | RAB9A (0.38) | CRACR2AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL6617216 | 0.80 | HPGD (0.43) | ALDH1A1HPGDCRACR2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |