Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617374 | 0.97 | TP53 (0.39) | TP53RXFP1KDM4ETSHRAADAT | |
| SCHEMBL6620062 | 0.95 | CNR1 (0.40) | TP53RXFP1KDM4ETSHRAADAT | |
| SCHEMBL6621748 | 0.94 | CNR1 (0.40) | TP53RXFP1KDM4ETSHRAADAT | |
| SCHEMBL6618283 | 0.92 | CNR1 (0.41) | TP53RXFP1KDM4ETSHRAADAT | |
| SCHEMBL6617183 | 0.91 | ALDH1A1 (0.40) | TP53KDM4EAADATRAB9ASMN1; SMN2 | |
| SCHEMBL6620401 | 0.88 | HRH3 (0.39) | TP53RXFP1KDM4ETSHRALDH1A1 | |
| SCHEMBL6615944 | 0.88 | ALDH1A1 (0.43) | TP53KDM4EAADATSMN1; SMN2ALDH1A1 | |
| SCHEMBL6618110 | 0.87 | RAB9A (0.38) | KDM4ETSHRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6617596 | 0.86 | KDM4E (0.40) | TP53KDM4EAADATALDH1A1HPGD | |
| SCHEMBL6617727 | 0.86 | GNRHR (0.39) | RAB9ASMN1; SMN2ALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |