Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.37 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606378 | 0.95 | CNR1 (0.40) | GNRHRACKR3POLBALDH1A1LMNA | |
| SCHEMBL6618495 | 0.91 | GNRHR (0.40) | GNRHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6617183 | 0.90 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6617068 | 0.90 | PKM (0.38) | ACKR3ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL6618491 | 0.89 | MEN1 (0.45) | POLBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6618271 | 0.88 | MAPT (0.41) | ACKR3RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6617708 | 0.88 | ACKR3 (0.41) | ACKR3POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL6617644 | 0.87 | ACKR3 (0.40) | ACKR3ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6615944 | 0.86 | ALDH1A1 (0.43) | POLBALDH1A1SMN1; SMN2SLC16A3SLC16A1 | |
| SCHEMBL6616528 | 0.86 | TP53 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |