Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.42 |
| ▸ | JAK2 | O60674 | 9/20 | 0.42 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609028 | 0.93 | TYK2 (0.43) | TYK2JAK2JAK1CRACR2ACDK9 | |
| SCHEMBL6617587 | 0.91 | JAK2 (0.36) | TYK2JAK2JAK1MEN1NPC1 | |
| SCHEMBL6603775 | 0.89 | TYK2 (0.41) | TYK2JAK2JAK1MEN1NPC1 | |
| SCHEMBL6620323 | 0.86 | TYK2 (0.41) | TYK2JAK2JAK1CRACR2ACDK9 | |
| SCHEMBL6617644 | 0.86 | ACKR3 (0.40) | TYK2JAK2JAK1CRACR2ACDK9 | |
| SCHEMBL6617735 | 0.85 | PKM (0.42) | NPC1RAB9A | |
| SCHEMBL6616450 | 0.85 | POLB (0.36) | TYK2JAK2JAK1MEN1NPC1 | |
| SCHEMBL6604492 | 0.85 | CRACR2A (0.39) | TYK2JAK2JAK1MEN1NPC1 | |
| SCHEMBL6614350 | 0.85 | ALDH1A1 (0.41) | JAK2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6620593 | 0.84 | HRH3 (0.39) | TYK2JAK2JAK1RAB9ACRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | disclosed |