Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905470 | 0.87 | OPRM1 (0.43) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL7771959 | 0.83 | TRPM8 (0.42) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL5981087 | 0.79 | TRPM8 (0.48) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL7766515 | 0.77 | TRPM8 (0.42) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL23697940 | 0.76 | TRPM8 (0.52) | TRPM8TRPA1TRPV1KCNA5EPHX1 | |
| SCHEMBL8821704 | 0.73 | TRPM8 (0.48) | TRPM8TRPA1TRPV1KCNA5EPHX1 | |
| SCHEMBL5981079 | 0.72 | TRPM8 (0.48) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL2332511 | 0.72 | TRPM8 (0.44) | OPRM1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL8854727 | 0.72 | TRPM8 (0.44) | TRPM8TRPA1TRPV1EPHX1ALDH1A1 | |
| SCHEMBL3671546 | 0.71 | TRPM8 (0.40) | TRPM8TRPA1TRPV1KCNA5EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451164-A2 | AMIDE DERIVATIVES HAVING IMPROVED SOLUBILITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003006440-A2 | AMIDE-CONTAINING COMPOUND HAVING IMPROVED SOLUBILITY AND METHOD OF IMPROVING THE SOLUBILITY OF AN AMIDE-CONTAINING COMPOUND | PHARMACIA & UPJOHN COMPANY (US) | 2003-01-23 | — | — | WO | disclosed |