Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.37 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619394 | 0.93 | ALDH1A1 (0.45) | KDM4ECNR1AADATALDH1A1KMT2A | |
| SCHEMBL6620062 | 0.91 | CNR1 (0.40) | KDM4ECNR1AADATALDH1A1KMT2A | |
| SCHEMBL6616479 | 0.91 | EPHX2 (0.38) | KDM4ERECQLALDH1A1KMT2APOLB | |
| SCHEMBL6621748 | 0.90 | CNR1 (0.40) | KDM4ECNR1AADATALDH1A1KMT2A | |
| SCHEMBL6617829 | 0.89 | ALDH1A1 (0.39) | KDM4EALDH1A1KMT2ATP53GAA | |
| SCHEMBL6617337 | 0.88 | CNR1 (0.39) | KDM4ECNR1ALDH1A1KCNJ6KCNJ5 | |
| SCHEMBL6606378 | 0.88 | CNR1 (0.40) | CNR1ALDH1A1KMT2ASLC16A3SLC16A1 | |
| SCHEMBL6615944 | 0.88 | ALDH1A1 (0.43) | KDM4EAADATALDH1A1KMT2ASLC16A3 | |
| SCHEMBL6618283 | 0.88 | CNR1 (0.41) | KDM4ECNR1AADATALDH1A1KMT2A | |
| SCHEMBL6622840 | 0.88 | PTGES (0.42) | KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |