Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617729 | 0.93 | EPHX2 (0.37) | EPHX2NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL6618859 | 0.93 | KMT2A (0.43) | EPHX2NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL6618110 | 0.91 | RAB9A (0.38) | EPHX2NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL6617596 | 0.91 | KDM4E (0.40) | KMT2AKDM4EALDH1A1RECQLPOLB | |
| SCHEMBL6617829 | 0.90 | ALDH1A1 (0.39) | NPC1RAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL6615297 | 0.89 | RAB9A (0.38) | EPHX2NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL6616981 | 0.88 | GNRHR (0.41) | EPHX2NPC1RAB9AL3MBTL1KMT2A | |
| SCHEMBL6617294 | 0.87 | SLC1A2 (0.39) | RAB9AKMT2AKDM4EALDH1A1CRACR2A | |
| SCHEMBL6618373 | 0.87 | NPC1 (0.39) | EPHX2NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL6616388 | 0.87 | NAMPT (0.37) | MAPTASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |