Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614960 | 0.92 | HRH3 (0.39) | PTGESHRH3TAOK1TAOK3EPHX2 | |
| SCHEMBL6618824 | 0.92 | HRH3 (0.41) | PTGESHRH3DRD2ADRA1AKDM4E | |
| SCHEMBL6603251 | 0.90 | HRH3 (0.41) | PTGESHRH3TAOK1TAOK3EPHX2 | |
| SCHEMBL6617317 | 0.90 | HRH3 (0.40) | PTGESHRH3KDM4ETAOK1TAOK3 | |
| SCHEMBL6618373 | 0.89 | NPC1 (0.39) | PTGESDRD2ADRA1AKDM4EEPHX2 | |
| SCHEMBL6617506 | 0.89 | HRH3 (0.41) | PTGESHRH3KDM4ETAOK1TAOK3 | |
| SCHEMBL6617100 | 0.88 | NPC1 (0.40) | DRD2ADRA1ARECQL | |
| SCHEMBL6617829 | 0.88 | ALDH1A1 (0.39) | DRD2KDM4E | |
| SCHEMBL6617596 | 0.88 | KDM4E (0.40) | KDM4ERECQL | |
| SCHEMBL6620292 | 0.88 | PTGES (0.40) | PTGESDRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |