Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618955 | 0.92 | JAK2 (0.40) | ACKR3LMNASMN1; SMN2MAPTCRACR2A | |
| SCHEMBL6618271 | 0.90 | MAPT (0.41) | ACKR3SMN1; SMN2MAPTTP53GAA | |
| SCHEMBL6620593 | 0.89 | HRH3 (0.39) | ACKR3MAPTCRACR2AJAK2TYK2 | |
| SCHEMBL6617068 | 0.89 | PKM (0.38) | ACKR3LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL6614679 | 0.88 | MAPT (0.42) | ACKR3LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL6622049 | 0.88 | RAB9A (0.39) | CRACR2AJAK2TYK2JAK1CDK9 | |
| SCHEMBL6615008 | 0.87 | SMN1; SMN2 (0.47) | ACKR3LMNASMN1; SMN2MAPTCRACR2A | |
| SCHEMBL6617954 | 0.87 | EPHX2 (0.40) | CRACR2AJAK2TYK2JAK1CDK9 | |
| SCHEMBL6618072 | 0.87 | MEN1 (0.43) | ACKR3LMNASMN1; SMN2MAPTGAA | |
| SCHEMBL6615311 | 0.87 | CHRM5 (0.42) | ACKR3MAPTTP53USP2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |