Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617954 | 0.93 | EPHX2 (0.40) | CRACR2AJAK2JAK1TYK2CDK9 | |
| SCHEMBL6618467 | 0.92 | RAB9A (0.39) | RAB9ACRACR2AMEN1KMT2AALDH2 | |
| SCHEMBL6620593 | 0.91 | HRH3 (0.39) | RAB9ACRACR2AALDH2JAK2JAK1 | |
| SCHEMBL6618429 | 0.90 | ACKR3 (0.44) | RAB9AMEN1KMT2ATYK2 | |
| SCHEMBL6619848 | 0.88 | PPARG (0.42) | RAB9AMEN1KMT2APPARGP2RX1 | |
| SCHEMBL6617644 | 0.88 | ACKR3 (0.40) | CRACR2AJAK2JAK1TYK2CDK9 | |
| SCHEMBL6618658 | 0.86 | PPARG (0.44) | RAB9AMEN1KMT2APPARGKCNJ6 | |
| SCHEMBL6619981 | 0.86 | ALDH1A1 (0.39) | RAB9AMEN1KMT2AERCC1ERCC4 | |
| SCHEMBL6617364 | 0.85 | CNR1 (0.42) | RAB9ACRACR2AJAK2JAK1TYK2 | |
| SCHEMBL6634119 | 0.85 | CNR1 (0.42) | RAB9ACRACR2AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |